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LIST OF PUBLICATIONS

2025

Zhao R, Zhang J, Schwarz EC, del Campo A, Hoth M, Qu B. 2024. T cell polarization and NFAT translocation are stiffness-dependent and are differentially regulated by Piezo1 and Orai1. Submitted (available on bioRxiv, doi: 10.1101/2024.03.06.583253) Link

Bereau G, Shaebani R, Naukamar S, Cowley N, Lautenbach M, Zhao R, Hawkins R, Aradilla L, Qu B^#, Lautenschläge F^#. The mechanism how Pretubulysin-induced microtubule disassembly improves T cell search efficiency. Under review

2024

Pei J, Zou D, Li L, Kang L, Sun M, Li X, Chen Q, Chen D, Qu B, Gao X, Lin Z. 2024. Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation. J Biol Chem 300:107319. Link

Yanamandra AK, Zhang J, Montalvo G, Zhou X, Biedenweg D, Zhao R, Sharma, S, Hoth M, Lautenschlaeger F, Otto O, del Campo A, Qu B. 2024. PIEZO1-mediated mechanosensing governs NK cell killing efficiency and infiltration in three-dimensional matrices. Eur J Immunol 54:2350693. Link

2023

Zhao R, Yanamandra AK, Qu B. 2023. A high-throughput 3D kinetic killing assay. Eur J Immunol 53:2350505. Link

Yanamandra AK, Bhusari S, del Campo A, Sandaran S^#, Qu B^#. 2023. In vitro evaluation of immune responses to bacterial hydrogels for the development of living therapeutic materials. Biomaterials Adv 153:213554. Link
Pagano G, Botana IF, Wierz M, Roessner PM, Ioannou N, Zhou X, Al-Hity G, Borne C, Gargiulo E, Gonder S, Qu B, Stamatopoulos B, Ramsay AG, Seiffert M, Largeot A, Moussay E, Paggetti J. 2023. Interleukin-27 potentiates CD8⁺ T-cell-mediated anti-tumor immunity in chronic lymphocytic leukemia. Haematologica 108:3011-24. Link
Dai X, Zhou X, Shao R, Zhao R, Yanamandra AK, Xing Z, Ding M, Wang J, Liu T, Zheng Q, Zhang P, Zhang H, Wang Yi, Qu B^#, Wang Yu^#. 2023. Bioactive constituents of Verbena Officinalis alleviate inflammation and enhance killing efficiency of natural killer cells. Int J Mol Sci 24:7144. Link

2022

Jung P, Zhou X, Iden S, Qu B, Bischoff M. 2022. Characterization of the elasticity of CD4⁺ T cells: An approach based on Peak Force Quantitative Nanomechanical mapping. Bio-protocol 12:e4383 (linked to Jung P, Zhou X, Iden S, Bischoff M, Qu B. eLife 2021) Link
Yang W, Denger A, Diener C, Küppers F, Soriano-Baguet L, Schäfer G, Yanamandra AK, Zhao R, Knörck A, Schwarz EC, Hart M, Lammert F, Prates-Roma L, Brenner D, Christidis G, Helms V, Meese E, Qu B. 2022. Unspecific CTL killing is enhanced by high glucose via TNF-related apoptosis-inducing ligand. Front Immunol 13:831680. Link
Cui F, Shen X, Cao B, Ji H, Liu J, Zhuang X, Zeng C, Qu B, Li S, Xu Y, Zhou Q. 2022. Bacterial identification and adhesive strength evaluation based on a mannose biosensor with dual-mode detection. Biosens Bioelectron 203: 114044. Link
Zhou X, Zhao R, Yanamandra AK, Hoth M, Qu B. 2022. Light-sheet scattering microscopy to visualize long-term interactions between cells and extracellular matrix.Front Immunol 13:828634. Link

2021

Jung P, Zhou X, Iden S, Bischoff M, Qu B. 2021. T cell stiffness is enhanced upon formation of immunological synapse. eLife 10:e66643. Link
Zhao R, Zhou X, Khan ES, Alansary D, Friedmann K, Yang W, Schwarz EC, del Campo A, Hoth M, Qu B. 2021. Targeting the microtubule-network rescues CTL killing efficiency in dense 3D matrices. Front Immunol 12:729820. Link
Zhu J, Yang W, Zhou X, Zöphel D, Soriano-Baguet L, Dolgener D, Carlein C, Hof C, Zhao R, Ye S, Schwarz EC, Brenner D, Roma LP, Qu B. 2021. High glucose enhances cytotoxic T lymphocyte-mediated cytotoxicity. Front Immunol 12:689337. Link
Zheng Y, Han MKL, Zhao R, Blass J, Zhang J, Zhou DW, Colard-Itté JR, Dattler D, Hoth M, García AJ, Qu B, Bennewitz R, Giuseppone N, del Campo A. 2021. Optoregulated Force Application to Cellular Receptors Using Molecular Motors. Nat Commun 12: 3580. Link
Liu Y, Zhao R, Reda B, Yang W, Hannig M^#, Qu B^#. 2021. Profiling of cytokines, chemokines and growth factors in saliva and gingival crevicular fluid. Cytokine 142: 155504. Link
Ji Q, Wang L, Liu J, Wu Y, Lv H, Wen Y, Shi L, Qu B, Szentmary N. 2021. Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP. Inflammation 44: 682–692. Link
Zhang J, Zhao R, Li B, Farrukh A, Hoth M, Qu B, del Campo A. 2021. Micropatterned soft hydrogels to study the interplay of receptors and forces in T cell activation. Acta Biomaterialia S1742-7061, 30617. Link
Vesperini D, Montalvo G, Qu B^#, Lautenschläger F^#. 2021. Characterization of immune cell migration using microfabrication. Biophys Rev 13: 185–202. Link

2020

Shu Y, Wang Y, Lv WQ, Peng DY, Li J, Zhang H, Jiang GJ, Yang BJ, Liu S, Zhang J, Chen YH, Tang S, Wan KX, Yuan JT, Guo W, Fu G, Qi XK, Liu ZD, Liu HY, Yang C, Zhang LH, Liu FJ, Yu J, Zhang PH, Qu B, Zhao H, He TC, Zou L. 2020. ARRB1-Promoted NOTCH1 degradation is suppressed by oncomiR miR-223 in T-cell acute lymphoblastic leukemia. Cancer Research 80: 988-98.
Sadjadi Z, Zhao R, Hoth M, Qu B, Rieger H. 2020. Migration of cytotoxic T lymphocytes in 3D collagen Matrices. Biophys J 119: 2141-2152. (selected as Highlight of the issue) Link
Zhou Y, Zhao R, Schwarz EC, Akbar R, Kaba M, Pattu V, Helms V, Rieger H, Nunes-Hasler P, Qu B. 2020. Interorganelle tethering to endocytic organelles determines directional cytokine transport in CD4⁺ T cells. J Immunol 205: 2988-3000. Link
Zou H, Yang W, Schwar G, Zhao R, Alansary D, Yin D, Schwarz EC, Niemeyer B, Qu B. 2020. High glucose distinctively regulates Ca²⁺ influx in cytotoxic T lymphocytes upon target-recognition and Thapsigargin-stimulation. Eur J Immunol 50: 2095-98. Link
Stankevicins L, Ecker N, Terriac E, Maiuri P, Schoppmeyer R, Vargas P, Lennon-Dumenil AM, Piel M, Qu B, Hoth M, Kruse K, Lautenschlager F. 2020. Deterministic actin waves as generators of cell polarization cues. Proc Natl Acad Sci USA 117: 826-35. Link

2018

Schoppmeyer R, Zhao R, Hoth M, Qu B. 2018. Light-sheet microscopy for three-dimensional visualization of human immune cells. J Vis Exp (136), e57651. Link
Zhou X, Friedmann K, Lyrmann H, Zhou Y, Schoppmeyer R, Knörck A, Mang S, Hoxha C, Angenendt A, Backes CS, Mangerich C, Zhao R, Cappello S, Schwär G, Hässig C, Neef M, Bufe B, Zufall F, Kruse K, Niemeyer BA, Lis A, Qu B, Kummerow C, Schwarz EC, Hoth M. 2018. A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity. J Physiol 596: 2681-2698. Link

2017

Yang R, Stocker S, Schott S, Heil J, Marme F, Cuk K, Chen B, Golatta M, Zhou Y, Sutter C, Wappenschmidt B, Schmutzler R, Bugert P, Qu B, Bartram CR, Sohn C, Schneeweiss A, Burwinkel B. 2017. The association between breast cancer and S100P methylation in peripheral blood by multicenter case-control studies. Carcinogenesis 38: 312-20.
Zhou X, Zhao R, Schwarz K, Mangeat M, Schwarz EC, Hamed M, Bogeski I, Helms V, Rieger H, Qu B. 2017. Bystander cells enhance NK cytotoxic efficiency by reducing search time. Sci Rep 7: 44357. Link
Schoppmeyer R, Zhao R, Cheng H, Hamed M, Liu C, Zhou X, Schwarz EC, Zhou Y, Knorck A, Schwar G, Ji S, Liu L, Long J, Helms V, Hoth M, Yu X^#, Qu B^#. 2017. Human profilin 1 is a negative regulator of CTL mediated cell-killing and migration. Eur J Immunol 47:1562-72. (Selected as Back Cover Story)

2016

Schwarz K, Schroder Y, Qu B, Hoth M, Rieger H. 2016. Optimality of Spatially Inhomogeneous Search Strategies. Physical Rev Lett 117: 068101.
Tang Q, Holland-Letz T, Slynko A, Cuk K, Marme F, Schott S, Heil J, Qu B, Golatta M, Bewerunge-Hudler M, Sutter C, Surowy H, Wappenschmidt B, Schmutzler R, Hoth M, Bugert P, Bartram CR, Sohn C, Schneeweiss A, Yang R, Burwinkel B. 2016. DNA methylation array analysis identifies breast cancer associated - RPTOR, MGRN1 and RAPSN hypomethylation in peripheral blood DNA. Oncotarget 7: 64191–202. Link
Bhat SS, Friedmann KS, Knorck A, Hoxha C, Leidinger P, Backes C, Meese E, Keller A, Rettig J, Hoth M, Qu B, Schwarz EC. 2016. Syntaxin 8 is required for efficient lytic granule trafficking in cytotoxic T lymphocytes. BBA-Mol Cell Res 1863: 1653-64. Link
Maccari I, Zhao R, Peglow M, Schwarz K, Hornak I, Pasche M, Quintana A, Hoth M, Qu B, Rieger H. 2016. Cytoskeleton rotation relocates mitochondria to the immunological synapse and increases calcium signals. Cell calcium 60:309-21. Link

2015

Yang R, Pfutze K, Zucknick M, Sutter C, Wappenschmidt B, Marme F, Qu B, Cuk K, Engel C, Schott S, Schneeweiss A, Brenner H, Claus R, Plass C, Bugert P, Hoth M, Sohn C, Schmutzler R, Bartram CR, Burwinkel B. 2015. DNA methylation array analyses identified breast cancer-associated HYAL2 methylation in peripheral blood. Int J Cancer 136: 1845-55.
Law JK, Susloparova A, Vu XT, Zhou X, Hempel F, Qu B, Hoth M, Ingebrandt S. 2015. Human T cells monitored by impedance spectrometry using field-effect transistor arrays: a novel tool for single-cell adhesion and migration studies. Biosens Bioelectron 15: 170-6. Link

2014

Kummerow C, Schwarz EC, Bufe B, Zufall F, Hoth M, Qu B. 2014. A simple, economic, time-resolved killing assay. Eur J Immunol 44: 1870-2. Link

2013

Yao W, Cai X, Liu C, Qin Y, Cheng H, Ji S, Xu W, Wu C, Chen T, Xu J, Long J, Fang Z, Qu B, Hoth M, Ni Q, Zha X, and Yu X. 2013. Profilin 1 potentiates apoptosis induced by staurosporine in cancer cells. Curr Mol Med 13: 417-428. Link
Shaw PJ^*, Qu B^*, Hoth M, Feske S. 2013. Molecular regulation of CRAC channels and their role in lymphocyte function. Cell Mol Life Sci 70: 2637-56. Link
Schwarz EC, Qu B, Hoth M. 2013. Calcium, cancer and killing: The role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells. BBA Molecular Cell Research 1833: 1603-11. Link

2012

Pattu V^*, Qu B^*, Schwarz EC, Strauss B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig J, Hoth M. 2012. SNARE protein expression and localization in human cytotoxic T lymphocytes. Eur J Immunol 42: 470-5. Link

2011

Qu B^*, Pattu V^*, Junker C, Schwarz EC, Bhat SS, Kummerow C, Marshall M, Matti U, Neumann F, Pfreundschuh M, Becherer U, Rieger H, Rettig J, Hoth M. 2011. Docking of lytic granules at the immunological synapse in human CTL requires Vti1b-dependent pairing with CD3 endosomes. J Immunol 186: 6894-904. Link
Pattu V^*, Qu B^*, Marshall M, Becherer U, Junker C, Matti U, Schwarz EC, Krause E, Hoth M, Rettig J. 2011. Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes. Traffic 12: 890-901. Link
Qu B, Al-Ansary D, Kummerow C, Hoth M, Schwarz EC. 2011. ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance. Cell calcium 50: 261-9. Link

2010

Bogeski I, Al-Ansary D, Qu B, Niemeyer BA, Hoth M, Peinelt C. 2010. Pharmacology of ORAI channels as a tool to understand their physiological functions. Expert Rev Clin Pharmacol. 3: 291-303. Link

2005

Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Wang F, Zhang X, Yang R, Fan F, Chen X, Pei G, Ma L. 2005. A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 123: 833-47. Link

2004

Gao H, Sun Y, Wu Y, Luan B, Wang Y, Qu B, Pei G. 2004. Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways. Mol Cell 14: 303-17. Link

2003

Lin GF, Geng X, Chen Y, Qu B, Wang F, Hu R, Ding X. 2003. T-box binding site mediates the dorsal activation of myf-5 in Xenopus gastrula embryos. Dev Dyn 226: 51-8. Link